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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jul 4, 2026

Modeling Cataract Surgery in Mice

Modeling Cataract Surgery in Mice

Published on: December 1, 2023

[Choroidal effusion after uncomplicated cataract surgery].

I Fromberg¹, M Krause, K Brückner

¹Augenheilkunde, Gemeinschaftspraxis, St. Wendel. irisfromberg@gmx.de

Klinische Monatsblatter Fur Augenheilkunde

|June 3, 2008

Summary

Angiotensin-converting enzyme (ACE) inhibitors may cause delayed angioedema, potentially leading to vision loss after cataract surgery. Preoperative evaluation for angioedema risk is crucial for patient safety.

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Last Updated: Jul 4, 2026

Modeling Cataract Surgery in Mice

Modeling Cataract Surgery in Mice

Published on: December 1, 2023

Area of Science:

Ophthalmology
Nephrology
Cardiology

Background:

Angiotensin-converting enzyme (ACE) inhibitors are associated with delayed angioedema, potentially exacerbated by surgical procedures.
Cataract surgery in a patient with hypertension and glomerulonephritis on ACE inhibitors led to postoperative complications.
Angioedema can manifest months or years after ACE inhibitor cessation and may be aggravated by local anesthesia.

Observation:

A 61-year-old patient developed eye pain and reduced vision post-cataract surgery.
Elevated intraocular pressure (28 mmHg) and shallow anterior chamber were noted.
Ophthalmoscopy revealed circumferential choroidal and focal exudative retinal detachment.

Findings:

Postoperative treatment with antiglaucoma medications, steroids, and antibiotics resolved elevated intraocular pressure and improved vision.
Choroidal detachment resolved within two weeks.
The patient had a history of minimal change glomerulonephritis and hypertension, treated with low-dose cortisone and an ACE inhibitor (ramipril).

Implications:

ACE inhibitor use may be linked to choroidal effusion, a potential cause of vision impairment after ocular surgery.
Consider alternative antihypertensive medications preoperatively in patients with a history of angioedema.
Glomerulonephritis may contribute to edema; thorough evaluation and treatment are recommended before elective surgery in such patients.