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Chromatin Packaging

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...

Chromatin Packaging

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter?
The chromatin
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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Related Experiment Video

Updated: Jul 4, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

Published on: October 1, 2017

Solitonic speed in DNA.

Slobodan Zdravković¹, Miljko V Satarić

¹Fakultet tehnickih nauka, Univerzitet u Pristini, Kosovska Mitrovica, Srbija. szdravk@etf.bg.ac.yu

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|June 4, 2008

Summary

We propose a single molecule experiment to measure solitonic wave speed in DNA. The study discusses potential speeds based on the Peyrard-Bishop-Dauxois model of DNA dynamics.

Area of Science:

Molecular Biophysics
Computational Biology

Background:

DNA possesses complex dynamics beyond simple base pairing.
Solitonic waves are nonlinear phenomena with potential roles in biological systems.

Purpose of the Study:

To propose a single-molecule experiment for measuring solitonic wave speed in DNA.
To estimate solitonic wave speeds using the Peyrard-Bishop-Dauxois model.

Main Methods:

Theoretical proposal for a single-molecule experiment.
Application of the Peyrard-Bishop-Dauxois (PBD) model for DNA dynamics.

Main Results:

A feasible experimental approach is outlined.
The PBD model predicts specific ranges for solitonic wave speeds in DNA.

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Studying DNA Looping by Single-Molecule FRET

Published on: June 28, 2014

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Last Updated: Jul 4, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

Published on: October 1, 2017

Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay

Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay

Published on: March 23, 2010

Studying DNA Looping by Single-Molecule FRET

Studying DNA Looping by Single-Molecule FRET

Published on: June 28, 2014

Conclusions:

Experimental measurement of solitonic wave speed in DNA is achievable.
The PBD model provides a theoretical framework for understanding these dynamics.