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Updated: Jul 4, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Intermittent relaxation in hierarchical energy landscapes
A Fischer1, K H Hoffmann, P Sibani
1Institut für Physik, Technische Universität Chemnitz, D-09107 Chemnitz, Germany. andreas.fischer@physik.tu-chemnitz.de
Abstract:
We numerically simulate a thermalization process in an energy landscape with hierarchically organized metastable states. The initial configuration is chosen to have a large energy excess relative to the thermal equilibrium value at the running temperature. We show that the initial energy surplus is dissipated in a series of intermittent bursts, or quakes, whose rate decreases as the inverse of the age of the system. In addition, one observes energy fluctuations with a zero-centered Gaussian distribution. These pertain to the pseudoequilibrium dynamics within a single metastable state and do not contribute to the energy dissipation. The derivative of the thermal energy with respect to the logarithm of time is asymptotically constant and comprises a temperature-independent part and a part with an Arrhenius temperature dependence. The findings closely mirror recent numerical simulation results obtained for microscopic glassy models. For these models, record-sized energy fluctuations have been claimed to trigger intermittent events during low-temperature thermalization. In the present model record-sized fluctuations are by construction needed to trigger changes from one metastable state to another. This property thus suffices to explain the statistical property of intermittent energy flow in complex metastable systems.
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