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Melting of branched RNA molecules
Ralf Bundschuh1, Robijn Bruinsma
1Department of Physics, Ohio State University, Columbus, Ohio 43210-1117, USA.
Abstract:
In this Letter we show that the melting thermodynamics of RNA molecules is very sensitive to the branching geometry. We find that, when pairing interactions are described by a Gō model, unbranched RNA molecules with a linear geometry melt via a conventional continuous phase transition with classical exponents while RNA molecules with the branching geometry of a Cayley tree, with coordination number three, have a free energy that shows no thermodynamic singularity within numerical precision. Nevertheless, we provide an analytical proof that the free energy does have a mathematical singularity at the stability limit of the ordered structure. The correlation length appears to diverge but only on the high-temperature side of this singularity.
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