Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells.

Communications biology·2026
Same author

A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8<sup>+</sup> infiltration in glioma.

Scientific reports·2025
Same author

IL-7-mediated expansion of autologous lymphocytes increases CD8<sup>+</sup> VLA-4 expression and accumulation in glioblastoma models.

bioRxiv : the preprint server for biology·2025
Same author

Circulating Interleukin-6 Levels and Timing of Acute Ischemic Stroke Onset.

Annals of clinical and translational neurology·2025
Same author

A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial.

Nature cancer·2025
Same author

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models.

The Journal of clinical investigation·2025

Related Experiment Video

Updated: Jul 4, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Combating immunosuppression in glioma.

Eleanor A Vega1, Michael W Graner, John H Sampson

  • 1Duke University School of Medicine, Department of Surgery, Division of Neurosurgery, 221 Sands Building, Durham, NC 27710, USA.

Future Oncology (London, England)
|June 4, 2008
PubMed
Summary

Combating immune suppression in malignant glioma patients by targeting TGF-beta signaling and regulatory T cells shows promise. These strategies may improve patient prognosis despite poor outcomes with current therapies.

More Related Videos

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Isolation and Purification of Fungal &#946;-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Related Experiment Videos

Last Updated: Jul 4, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Isolation and Purification of Fungal &#946;-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Area of Science:

  • Neuro-oncology
  • Immunology

Background:

  • Malignant gliomas have a poor prognosis despite maximal therapy.
  • Patients exhibit immune defects, including CD4 lymphopenia and increased regulatory T cells, shifting cytokine profiles from Th1 to Th2.

Purpose of the Study:

  • To explore strategies for combating immunosuppression in malignant glioma.
  • Focus on inhibiting TGF-beta signaling and modulating regulatory T cells.

Main Methods:

  • Inhibiting TGF-beta signaling via antisense oligonucleotides, kinase inhibitors, soluble receptors, or antibodies.
  • Targeting regulatory T cells using antibodies against CD25, CTLA-4, GITR, or vaccination against Foxp3.

Main Results:

  • Studies targeting immunosuppression have yielded encouraging results.
  • Combating immune suppression is a potential key to improving malignant glioma prognosis.

Conclusions:

  • Targeting TGF-beta signaling and regulatory T cells are promising strategies for malignant glioma.
  • Overcoming immune suppression may enhance treatment outcomes for glioma patients.