Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression
M W Mellencamp1, P C O'Brien, J R Stevenson
1Department of Microbiology, Miami University, Oxford, Ohio 45056.
Journal of Virology
|June 1, 1991
Abstract:
The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism.
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