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Updated: Jul 4, 2026
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Mantle cell lymphoma with aberrant expression of CD10
1Department of Pathology, City Hospital, Birmingham, UK. ulises.zanetto@swbh.nhs.uk
Histopathology
|June 4, 2008
Summary
CD10 expression in mantle cell lymphoma (MCL) often presents with variant features, but does not indicate origin from germinal center B cells. This finding aids in diagnosing and managing this complex lymphoma.
Area of Science:
- Hematology
- Oncology
- Immunophenotyping
Background:
- Mantle cell lymphoma (MCL) exhibits significant heterogeneity, complicating diagnosis and treatment.
- Aberrant marker expression, such as CD10, can further challenge accurate classification.
Purpose of the Study:
- To investigate the clinical and pathological characteristics of MCL with CD10 expression.
- To understand the implications of CD10 positivity in MCL morphology, immunophenotype, and genetics.
Main Methods:
- Analysis of 17 MCL specimens from 13 patients.
- Immunophenotypic analysis including CD10, cyclin D1, CD5, and Bcl-6 expression.
- Genetic analysis including CCND1-IGH translocation and BCL-6 alterations.
- Sequencing of immunoglobulin heavy chain variable region (IGHV).
Main Results:
- 14 of 17 MCL specimens expressed CD10; all expressed cyclin D1 and had the t(11;14) translocation.
- MCL cases with CD10 often showed disseminated disease and an adverse clinical course.
- Variant features included blastoid morphology, CD5 negativity, Bcl-6 expression (with BCL-6 alterations in some), and lack of significant somatic mutation in IGHV, suggesting non-germinal center origin.
Conclusions:
- CD10 expression in MCL is frequently associated with diverse morphological, immunophenotypic, and genetic anomalies.
- The presence of CD10 does not signify derivation from germinal center B cells in MCL.
- Understanding these variant features is crucial for accurate MCL diagnosis and management.
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