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Related Experiment Video

Updated: Jul 4, 2026

Restraint to Induce Stress in Mice and Rats

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

Context and strain-dependent behavioral response to stress.

Katarzyna Nosek¹, Kristen Dennis, Brian M Andrus

¹Northwestern University Feinberg School of Medicine, The Asher Center, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, USA. e-redei@northwestern.edu.

Behavioral and Brain Functions : BBF

|June 4, 2008

Summary

This summary is machine-generated.

Strain differences in stress-reactivity influence rat behavior in anxiety tests. Repeated testing can mitigate these strain-specific responses, suggesting context-dependent learning impacts anxiety measures.

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Area of Science:

Neuroscience
Animal Behavior

Background:

Strain differences in anxiety measures are known.
Behavioral responses to acute stress are not well characterized across strains.

Purpose of the Study:

Investigate if strain differences in stress-reactivity lead to differential behavioral responses in anxiety tests.
Characterize strain differences in behavioral responses to acute prior stress.

Main Methods:

Studied male Fisher 344 (F344) and Wistar Kyoto (WKY) rats under basal and post-stress conditions.
Utilized elevated plus maze (EPM) and open field (OFT) to assess anxiety-like behaviors, activity, exploration, rearing, and grooming.
Differentiated effects of novelty and prior stress through repeated testing.

Main Results:

Prior environment exposure increased anxiety measures in both strains, indicating context-dependent learning.
Activity decreased with repeated testing; prior stress reduced activity in OFT, reversed by re-testing.
Prior stress decreased EPM anxiety in F344 rats, but increased OFT freezing in WKY rats.

Conclusions:

Test stressfulness predicts strain behavior based on stress-reactivity and coping styles.
Repeated testing can partially overcome strain-specific behavioral differences in anxiety paradigms.