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Perirenal schwannoma: a case report
Mona El-Bahrawy1, Bijan Khoubehi, David Hrouda
1Department of Histopathology, Division of Investigative Science, Imperial College, Hammersmith Hospital, DuCane Road, London, UK. m.elbahrawy@imperial.ac.uk
Journal of Medical Case Reports
|June 4, 2008
Summary
This study reports the first case of a rare kidney nerve sheath tumor, a cellular schwannoma, located on the lateral border of the kidney. Immunohistochemistry confirmed the diagnosis and highlighted antibody panels for diagnosing spindle cell neoplasms.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Nerve sheath tumors of the kidney are exceptionally rare.
- Previous cases have been exclusively located in the kidney's hilar region.
Purpose of the Study:
- To report a unique case of a cellular schwannoma presenting at the lateral border of the kidney.
- To emphasize the diagnostic utility of immunohistochemistry in differentiating renal spindle cell neoplasms.
Main Methods:
- Histopathological examination of a renal tumor.
- Immunohistochemical analysis using a panel of antibodies including cytokeratins, epithelial membrane antigen, S-100 protein, and glial fibrillary acidic protein.
Main Results:
- The tumor was characterized as a spindle cell lesion.
- Immunohistochemistry revealed strong, diffuse expression of cytokeratins and positive staining for S-100 protein and glial fibrillary acidic protein.
- The tumor cells were negative for epithelial membrane antigen.
Conclusions:
- This represents the first documented case of a cellular schwannoma occurring at the lateral border of the kidney.
- The findings underscore the importance of a comprehensive antibody panel for accurate diagnosis of renal spindle cell neoplasms.
