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Updated: Jul 4, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
Dendritic cells based immunotherapy of patient with chondrosarcoma--case report
Jacek Tabarkiewicz1, Sebastian Radej, Iwona Hus
1Department of Clinical Immunology, Skubiszewski Medical University of Lublin, 20-095 Lublin, Poland. tabar@mp.pl
Abstract:
We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.

