Related Experiment Video
Updated: Jul 4, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
Neurologic consequences of autoimmune polyglandular syndrome type 1
Joseph R Berger1, Allison Weaver, John Greenlee
1Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L-445, 740 S. Limestone Street, Lexington, KY 40536-0284, USA. jrbneuro@uky.edu
Background:
Autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive disorder that is chiefly characterized by polyendocrinopathy, chronic mucocutaneous candidiasis, and ectodermal dystrophy. The neurologic complications of this disorder have not been well characterized.
Method:
The authors report a patient with a previously undescribed autoimmune cerebellar degeneration occurring in association with APS-1 and review the literature regarding the neurologic complications of this disorder.
Results:
This 24-year-old woman with APS-1 presented with gait ataxia associated with band-like hyperintense signal abnormalities of both cerebellar hemispheres and a unique antibody to cerebellar Purkinje cells and brainstem neurons. At age 9, she had C. Miller Fisher syndrome, from which she had fully recovered.
Conclusions:
Autoimmune neurologic disease may develop with autoimmune polyglandular syndrome type 1. Neurologic disease may also result from the associated endocrinopathies (hypoparathyroidism, hypothyroidism, diabetes mellitus), vitamin deficiency (vitamins B12 and E), and celiac sprue.
More Related Videos
Related Concept Videos
Type I Diabetes II: Pathophysiology
Type I Diabetes I: Introduction
Type I Diabetes III: Clinical Manifestations
Multiple Sclerosis l: Introduction
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Graves' Disease I: Introduction

