Related Experiment Video
Updated: Jul 4, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Management of neurobrucellosis: an assessment of 11 cases
Hanefi Cem Gul1, Hakan Erdem, Levent Gorenek
1Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Hospital, Ankara, Turkey. hcgul@yahoo.com
Objective:
The central nervous system involvement of Brucellosis causes a hard to treat infection with multiple sequelae. The aim of this paper is to discuss the course of neurobrucellosis in response to therapy.
Patients And Methods:
Patients with neurobrucellosis were evaluated. The diagnosis was established by the isolation of bacteria, abnormal CSF findings and positive serology. Ceftriaxone, rifampicin, doxycycline and trimethoprim sulfamethoxazole were the antibiotic choices for these cases.
Results:
We present 11 cases with neurobrucellosis. None of our patients died, albeit one case has a critical situation due to subarachnoid hemorrhage and its' concordant sequelae. Only one of four patients with walking difficulty and two with hearing loss were normalized with therapy. Imaging techniques did not provide any specific contribution regarding the Brucella infection.
Conclusions:
Parenteral ceftriaxone should be used as an initial alternative in the management of neurobrucellosis. Although the therapy should be individualized, the duration of therapy should be a minimum of six months with suitable antibiotics.
More Related Videos
Related Concept Videos
Brain Abscess l: Introduction
Rocky Mountain Spotted Fever
Nephrotic Syndrome II : Assessment and Medical Management
Toxoplasmosis
Arboviral Encephalitis
Acute Pyelonephritis II: Diagnostic Studies and Management

