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Intoxication with over-the-counter antitussive medication containing dihydrocodeine and chlorpheniramine causes
Satoshi Murao1, Hiroaki Manabe, Tetsuji Yamashita
1Department of Internal Medicine, Matsuyama Shimin Hospital, Matsuyama. smurao@matsuyama-shimin-hsp.or.jp
Abstract:
We report a 35-year-old man who was referred to our hospital with generalized convulsion and mixed acidosis presumably caused by abuse of SS-BRON tablets, an over-the-counter (OTC) antitussive medication sold in Japan. These tablets contain dihydrocodeine phosphate, methylephedrine, chlorpheniramine, and caffeine. Although it is difficult to discern which component caused these symptoms, it seems that dihydrocodeine phosphate or methylephedrine was involved in the addiction to SS-BRON and chlorpheniramine may have caused the generalized convulsion. It should be recognized that an OTC antitussive, which is quite easy to obtain, can be abused and subsequently induce serious intoxication.
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