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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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[Gastroesophageal reflux disease in preschool children with asthma]

Yukinori Yoshida1, Makoto Kameda, Tomoki Nishikido

  • 1Department of Pediatrics, Osaka Prefectural Hospital Organization Osaka Prefectural Medical Center for Respiratory and Allergic Disease. yukii@hbk.pref,osaka.jp

Arerugi = [Allergy]
|June 4, 2008
PubMed

Insights

Pediatric intractable asthma may be linked to gastroesophageal reflux disease (GERD). Treating GERD with famotidine effectively reduced respiratory symptoms in most GERD-positive children with asthma.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology

Context:

  • Pediatric intractable asthma often presents challenges in management.
  • Gastroesophageal reflux disease (GERD) is occasionally associated with pediatric asthma, but diagnostic criteria and treatment efficacy remain unclear.

Purpose:

  • To investigate the incidence of GERD in preschool children with intractable asthma.
  • To evaluate the effectiveness of famotidine treatment for GERD in this population.

Summary:

  • A retrospective study of 27 preschool children (<6 years) with recurrent asthma attacks despite therapy revealed a 66.7% incidence of GERD via 24-hour esophageal pH monitoring.
  • Of 15 GERD-positive patients treated with famotidine, 80% experienced decreased respiratory symptoms, particularly cough and wheeze during waking hours, correlating with acid reflux patterns.

Impact:

  • Findings suggest that GERD should be investigated in children with persistent asthma.
  • This study highlights the potential therapeutic benefit of addressing GERD in pediatric asthma management.
Abstract

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