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Potential role of CD8+CD28- T lymphocytes in immune activation during HIV-1 infection

Nancy Vivar1, Pham Hong Thang, Ann Atlas

  • 1Department of Microbiology, Cell and Tumor Biology, Karolinska Institute, Stockholm, Sweden.

AIDS (London, England)
|June 4, 2008
PubMed

As CD8+CD28- T cells have been associated with dendritic and T cell suppression, we analyzed whether an increase in CD8+CD28- T cell numbers during HIV-1 infection could lead to impaired T cell responses. In contrast to the in-vitro generated CD8+CD28- suppressors, peripheral blood CD8+CD28- T cells of both HIV-infected and noninfected individuals promoted dendritic cell activation. The CD8+CD28- T cell accumulation during HIV-1 infection may thus contribute to accelerated inflammatory reactions and immune activation.

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