Related Experiment Videos
[Useful and pointless steroid determinations: appropriate laboratory diagnosis of adrenal cortex function]
1Medizinische Klinik des Universitätsspitals Zürich.
Schweizerische Medizinische Wochenschrift
|April 6, 1991
Summary
Plasma cortisol tests are now superior to older urinary 17-hydroxycorticoids for assessing adrenocortical function. Modern methods aid in diagnosing conditions like Cushing's syndrome and adrenal failure.
Area of Science:
- Endocrinology
- Clinical Chemistry
Context:
- Adrenocortical function assessment has evolved significantly.
- Urinary 17-hydroxycorticoids were previously the standard diagnostic tool.
- Current diagnostic capabilities offer greater specificity and reliability.
Purpose:
- To outline current, reliable methods for assessing adrenocortical function.
- To differentiate between historical and modern diagnostic approaches.
- To guide the diagnosis of endocrine disorders like Cushing's syndrome and adrenal insufficiency.
Summary:
- Plasma cortisol measurements via radioimmunoassay are more specific and reliable than historical urinary 17-hydroxycorticoids.
- Functional tests, suitable for ambulatory patients, complement plasma cortisol assays.
- Appropriate tests for diagnosing Cushing's syndrome and adrenocortical failure are discussed.
Impact:
- Facilitates accurate diagnosis and exclusion of critical endocrine conditions.
- Improves patient management through reliable functional testing.
- Highlights the importance of clinical evaluation over steroid analysis for treatment monitoring in adrenal insufficiency.