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Updated: Jul 4, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Published on: October 12, 2017

Multiple actions of high-density lipoprotein.

Matilda Florentin1, Evangelos N Liberopoulos, Anthony S Wierzbicki

  • 1Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Current Opinion in Cardiology
|June 4, 2008
PubMed
Summary

High-density lipoprotein (HDL) offers benefits beyond cholesterol transport, including anti-inflammatory and antioxidant effects. However, HDL can become dysfunctional, highlighting the need for further research into its complex roles in vascular health.

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • High-density lipoprotein (HDL) is primarily known for reverse cholesterol transport.
  • HDL's antiatherogenic role may involve additional beneficial functions.
  • Understanding these functions is crucial for cardiovascular disease prevention.

Purpose of the Study:

  • To review the actions of high-density lipoprotein (HDL) beyond reverse cholesterol transport.
  • To explore HDL's contributions to its antiatherogenic properties.
  • To consolidate current knowledge on HDL's multifaceted roles.

Main Methods:

  • Literature review of studies on high-density lipoprotein (HDL) function.
  • Analysis of research investigating HDL's effects on oxidation, inflammation, thrombosis, and endothelial function.
  • Examination of HDL-associated enzymes and their roles.

Main Results:

  • HDL cholesterol levels show an inverse correlation with coronary heart disease and vascular disease.
  • HDL exhibits protective effects against oxidation, inflammation, thrombosis, and improves endothelial function.
  • HDL-associated enzymes like paraoxonase and platelet-activating factor acetylhydrolase contribute to these effects, but HDL can also become dysfunctional.

Conclusions:

  • High-density lipoprotein (HDL) possesses diverse properties beyond cholesterol transport.
  • The precise role of HDL in cardiovascular health requires further investigation.
  • Future research should focus on elucidating the complexities of HDL function and dysfunction.