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Published on: October 12, 2017

High-density lipoprotein and atheroma monitoring

Stephen J Nicholls1, E Murat Tuzcu

  • 1Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. nichols1@ccf.org

Current Opinion in Cardiology
|June 4, 2008
PubMed

Insights

Arterial wall imaging effectively evaluates therapies targeting high-density lipoproteins (HDL). These therapies show beneficial effects on atherosclerosis, making imaging crucial for developing new HDL-focused treatments.

Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Pharmacology

Background:

  • High-density lipoproteins (HDL) play a key role in managing atherosclerosis.
  • HDL's biological properties influence plaque extent and composition.

Purpose of the Study:

  • To review the application of arterial wall imaging.
  • To assess the impact of therapies that enhance HDL functionality.

Main Methods:

  • Utilizing arterial wall imaging techniques.
  • Analyzing data from studies on HDL-modifying therapies.

Main Results:

  • Arterial wall imaging demonstrates HDL-therapies' positive effects on atherosclerosis.
  • HDL-targeted treatments show promise in managing cardiovascular disease.

Conclusions:

  • Atheroma imaging is essential for clinical trials of novel HDL therapies.
  • This imaging modality aids in developing drugs that promote HDL's atheroprotective effects.
Abstract

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