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Published on: July 5, 2021
Nasopharyngeal carcinoma with orbital involvement
Kelvin Y C Lee1, Lay-Leng Seah, Sharon Tow
1Singapore National Eye Centre, Singapore. kelvin.lee.y.c@singhealth.com.sg
Ophthalmic Plastic and Reconstructive Surgery
|June 4, 2008
Summary
Nasopharyngeal carcinoma can present with orbital involvement, sometimes as an initial sign of recurrence. Early recognition of eye symptoms like eyelid mass or tearing in patients with a history of nasopharyngeal carcinoma is crucial for prompt treatment.
Area of Science:
- Ophthalmology
- Oncology
- Head and Neck Surgery
Background:
- Nasopharyngeal carcinoma (NPC) is a malignancy with potential for distant metastasis.
- Orbital involvement in NPC can present with varied clinical signs and symptoms.
Purpose of the Study:
- To delineate the clinical presentation of patients diagnosed with nasopharyngeal carcinoma (NPC) and subsequent orbital involvement.
- To understand the diagnostic and prognostic implications of orbital invasion in NPC patients.
Main Methods:
- A retrospective case series was conducted involving 9 patients with NPC and orbital involvement.
- Clinical data, neuroradiologic findings, and patient outcomes were analyzed.
Main Results:
- The study included 9 patients (3 female, 6 male) with stage T4 NPC, mean age 49.2 years.
- Orbital involvement occurred a mean of 8.2 years post-NPC diagnosis; 4 patients presented with eyelid mass, 2 with tearing.
- Imaging confirmed orbital apex, inferior orbital fissure, and lacrimal sac involvement; 3 patients died from advanced NPC.
Conclusions:
- Ocular symptoms can be the initial manifestation of recurrent nasopharyngeal carcinoma.
- Awareness of potential NPC recurrence in patients with prior history presenting with tearing or eyelid mass is vital for timely referral and management.