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Related Experiment Video

Updated: Jul 4, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Osteoplasty using calcium hydroxylapatite filler.

M Reza Vagefi1, Tristan F W McMullan, John D McCann

  • 1Center for Facial Appearances, Salt Lake City, Utah, U.S.A.

Ophthalmic Plastic and Reconstructive Surgery
|June 4, 2008
PubMed
Summary

Injectable calcium hydroxylapatite (Radiesse) offers a new, simple method for correcting small skull bony defects. This semipermanent technique shows promise for aesthetic improvement with no observed complications in a preliminary study.

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Area of Science:

  • Aesthetic surgery
  • Dermatology
  • Plastic surgery

Background:

  • Small bony defects in the skull can result from trauma or surgery, impacting aesthetics.
  • Current correction methods may be invasive or lack semipermanent solutions.

Observation:

  • A prospective case series evaluated injectable calcium hydroxylapatite (Radiesse) for skull defect correction.
  • Three patients with frontal bone defects received local injections of calcium hydroxylapatite filler.
  • Procedures were performed in an ambulatory surgical center under monitored anesthesia care.

Findings:

  • All three patients showed improved volume and aesthetics after receiving 1-3 vials of calcium hydroxylapatite.
  • No complications were reported during the follow-up period, which ranged from 2 to 7 months.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Last Updated: Jul 4, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

  • The volume replacement was easily titrated, suggesting potential for repeat treatments if needed.

    • Implications:

    • Injectable calcium hydroxylapatite presents a novel, simple, and semipermanent technique for aesthetic skull defect correction.
    • The procedure is potentially adaptable to an office setting with local anesthesia.
    • Further research with larger cohorts and longer follow-up is needed to confirm efficacy and duration.