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Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary
S H Murch1, E P Carter, S Tsagarakis
1Department of Child Health, St. Bartholomew's Hospital, London, UK.
Acta Paediatrica Scandinavica
|February 1, 1991
Abstract:
An 8-year-old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin-releasing factor (CRF-41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.