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Plasma cyclic AMP response to intravenous parathyroid hormone in pseudohypoparathyroidism

H F Stirling1, J A Darling, D G Barr

  • 1Royal Hospital for Sick Children, Edinburgh, Scotland, UK.

Acta Paediatrica Scandinavica
|March 1, 1991
PubMed

Insights

A simplified test using bovine parathyroid hormone (PTH) effectively identifies pseudohypoparathyroidism by measuring plasma cyclic AMP. This method is advantageous for screening in children and adults.

Area of Science:

  • Endocrinology
  • Biochemistry
  • Pediatrics

Background:

  • Pseudohypoparathyroidism (PHP) diagnosis traditionally involves complex tests.
  • Assessing parathyroid hormone (PTH) responsiveness is crucial for mineral metabolism disorders.

Purpose of the Study:

  • To evaluate a simplified diagnostic test for pseudohypoparathyroidism.
  • To assess the utility of plasma cyclic AMP response to bovine PTH in distinguishing PHP from normal controls.

Main Methods:

  • Intravenous bolus injection of highly purified bovine parathyroid hormone (PTH).
  • Measurement of basal and 10-minute plasma cyclic AMP levels.
  • Study included patients with mineral metabolism disorders and adult controls, as well as infants.

Main Results:

  • Plasma cyclic AMP levels reliably discriminated between normal responses and pseudohypoparathyroidism.
  • Infants under 3 months showed higher basal cyclic AMP and a blunted response to PTH.
  • The simplified test demonstrated advantages over traditional methods involving urine collection.

Conclusions:

  • This simplified test using bovine PTH and plasma cyclic AMP is effective for diagnosing pseudohypoparathyroidism.
  • The test is suitable for selective screening in individuals with suspected PHP, including infants.
  • It offers a less invasive and more efficient alternative to existing diagnostic procedures.

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