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Published on: March 23, 2016
Neuroprotection in glaucoma: drug-based approaches
William Cheung1, Li Guo, M Francesca Cordeiro
1Glaucoma & Retinal Degeneration Research Group, UCL Institute of Ophthalmology, London, UK.
Summary
Glaucoma research now emphasizes neuroprotection due to limitations in intraocular pressure management. This review explores drug-based neuroprotective strategies, including those used for Alzheimer's disease, to prevent retinal ganglion cell death.
Area of Science:
- Ophthalmology
- Neuroscience
- Pharmacology
Background:
- Traditional glaucoma management focusing on intraocular pressure is insufficient for preventing progressive vision loss.
- Retinal ganglion cell death is a key feature of glaucomatous optic neuropathy.
- Glaucomatous neurodegeneration shares similarities with central nervous system neurodegenerative diseases like Alzheimer's disease.
Purpose of the Study:
- To review current neuroprotective drug-based strategies for glaucoma management.
- To explore the potential of repurposed central nervous system drugs for glaucoma treatment.
Main Methods:
- Literature review of neuroprotective drug-based strategies in glaucoma.
- Examination of the link between glaucoma and Alzheimer's disease cellular processes.
- Analysis of ongoing clinical trials, such as memantine for primary open-angle glaucoma.
Main Results:
- Neuroprotective drugs show promise in reducing retinal ganglion cell death.
- Repurposing drugs from central nervous system diseases is a growing trend in glaucoma research.
- Clinical trial results for memantine in primary open-angle glaucoma are pending.
Conclusions:
- Neuroprotection represents a significant shift in glaucoma research strategy.
- Drug-based neuroprotection offers a potential avenue to halt glaucomatous neurodegeneration.
- Further research and clinical trials are crucial to validate these emerging therapeutic approaches.
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