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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jul 4, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

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Published on: May 25, 2020

Ocular Response Analyzer in subjects with and without glaucoma.

Michael Sullivan-Mee1, Shavon C Billingsley, Amita D Patel

  • 1Albuquerque VA Medical Center, Albuquerque, New Mexico 87108, USA. Michael.Sullivan-Mee@med.va.gov

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|June 4, 2008
PubMed
Summary

The Ocular Response Analyzer (ORA) can help distinguish glaucoma patients by measuring corneal biomechanics. Key ORA variables like corneal hysteresis (CH) and intraocular pressure (IOP) difference (DIOP) show potential in diagnosing glaucoma.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Background:

  • Intraocular pressure (IOP) assessment is crucial for diagnosing glaucoma.
  • Traditional tonometry may not fully account for corneal biomechanical properties.
  • The Ocular Response Analyzer (ORA) integrates corneal biomechanical data for improved IOP estimation.

Purpose of the Study:

  • To investigate the utility of ORA-derived IOP and corneal biomechanical variables in differentiating primary open-angle glaucoma (GLC) patients from healthy individuals.
  • To assess the discriminatory power of ORA parameters across different diagnostic groups (normal, ocular hypertension, glaucoma suspect, glaucoma).

Main Methods:

  • Retrospective analysis of patients from an eye clinic with acceptable ORA signal profiles.
  • Comparison of demographic, clinical, and ORA-derived variables (IOPg, IOPcc, CRF, CH, DIOP) across normal, ocular hypertension, glaucoma suspect, and GLC groups.
  • Statistical analysis including ANOVA and multivariate regression to identify discriminating factors.

Main Results:

  • The glaucoma group exhibited higher mean age, higher mean DIOP, and lower mean CH compared to other groups.
  • Multivariate analyses identified age, IOPcc, and DIOP as independent discriminators between GLC and normal subjects.
  • Age and IOPcc distinguished GLC from glaucoma suspects, while age and CRF differentiated GLC from ocular hypertension.

Conclusions:

  • ORA-generated parameters, including corneal hysteresis and IOP difference, show promise in differentiating glaucoma patients.
  • The effectiveness of ORA variables in diagnosis varies depending on the specific comparison groups.
  • Glaucoma patients may have their IOP significantly underestimated by conventional methods.