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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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The international spinal cord injury pain basic data set.

E Widerström-Noga1, F Biering-Sørensen, T Bryce

  • 1VA Medical Center, Miami, FL, USA. ewiderstrom-noga@miami.edu

Spinal Cord
|June 4, 2008
PubMed
Summary

A new International Spinal Cord Injury Basic Pain Data Set (ISCIPDS:B) was developed to standardize pain assessment in spinal cord injury (SCI) patients. This core data set aids consistent collection and reporting of SCI-related pain information.

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Clinical Epidemiology

Background:

  • Pain is a prevalent and complex issue in individuals with spinal cord injury (SCI).
  • Existing methods for collecting pain data in SCI populations lack standardization, hindering consistent research and clinical practice.
  • A unified approach is needed to capture essential pain characteristics in SCI.

Purpose of the Study:

  • To develop a foundational data set for consistent pain assessment in the SCI population.
  • To establish the International Spinal Cord Injury Basic Pain Data Set (ISCIPDS:B) within the existing International SCI data sets framework.
  • To facilitate standardized collection and reporting of SCI-related pain.

Main Methods:

  • A multidisciplinary working group with expertise in SCI pain was convened.
  • Members were appointed by leading international SCI and pain organizations (ISCoS, ASIA, APS, IASP).
  • The draft data set underwent iterative revisions based on feedback from expert committees, boards, and individual reviewers.

Main Results:

  • The final ISCIPDS:B includes core questions for clinically relevant SCI pain information.
  • It covers pain severity, physical and emotional function, pain intensity, classification, and temporal patterns.
  • The data set evaluates pain's impact on physical, social, and emotional functioning, as well as sleep.

Conclusions:

  • The ISCIPDS:B provides a standardized tool for collecting essential SCI-related pain data.
  • This data set enables consistent assessment by healthcare professionals across various clinical settings.
  • Implementation of ISCIPDS:B will improve the quality and comparability of pain research and clinical management in SCI.