Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Multi-focal, multi-centric angiosarcoma of bone.

E Kakouri1, J S Whelan, S Coltart

  • 1The London Soft Tissue & Bone Tumour Service The Meyerstein Institute of Oncology The Middlesex Hospital Mortimer Street London W1N 8AA UK.

Sarcoma
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of oncotype DX testing on adjuvant chemotherapy decision making in breast cancer with micrometastasis to the sentinel lymph node.

Annals of the Royal College of Surgeons of England·2025
Same author

Screening for pre-eclampsia by maternal serum glycosylated fibronectin and angiogenic markers at 36 weeks' gestation.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

BRCA1 and BRCA2 mutation testing in Cyprus; a population based study.

Clinical genetics·2016
Same author

Trends in survival for teenagers and young adults with cancer in the UK 1992-2006.

European journal of cancer (Oxford, England : 1990)·2015
Same author

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

ENCCA WP17-WP7 consensus paper on teenagers and young adults (TYA) with bone sarcomas.

Annals of oncology : official journal of the European Society for Medical Oncology·2014

This case study describes a rare, multi-focal angiosarcoma of bone in a 55-year-old man. Despite doxorubicin treatment, the patient succumbed to pulmonary thromboembolism.

Area of Science:

  • Oncology
  • Vascular Biology
  • Pathology

Background:

  • Angiosarcoma is a rare malignant vascular tumor.
  • Bone angiosarcomas are exceptionally rare, often presenting with aggressive behavior.
  • Multi-focal and multi-centric presentations are uncommon.

Purpose of the Study:

  • To describe a unique case of multi-focal, multi-centric angiosarcoma of bone.
  • To detail the clinical, radiological, and histological features of this rare entity.
  • To discuss the treatment response and outcome.

Main Methods:

  • Case report of a 55-year-old male patient.
  • Clinical presentation with pain and weight loss.
  • Radiological imaging (lytic lesions in long bones and pelvis).

More Related Videos

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
12:23

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

Related Experiment Videos

Last Updated: Jul 4, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
12:23

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

  • Histopathological examination with immunohistochemistry (CD31, CD34, von Willebrand factor).
  • Assessment of response to radiotherapy and doxorubicin chemotherapy.

    • Main Results:

    • Diagnosis of a predominantly low-grade angiosarcoma with focal intermediate-grade areas.
    • Tumor cells expressed endothelial markers CD31, CD34, and von Willebrand factor.
    • Rapid radiological progression despite radiotherapy.
    • Temporary pain relief with doxorubicin.
    • Death due to pulmonary thromboembolism 14 days after chemotherapy initiation.

    Conclusions:

    • Multi-focal angiosarcoma of bone is an aggressive malignancy with a poor prognosis.
    • Immunohistochemistry is crucial for diagnosing vascular tumors.
    • Treatment options remain limited, and complications like thromboembolism are significant concerns.