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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

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Clear cell chondrosarcoma of bone.

K S Ayoub1, R J Grimer, S R Carter

  • 1The Royal Orthopaedic Hospital Oncology Service The Royal Orthopaedic Hospital NHS Trust Bristol Road South Northfield Birmingham B31 2AP UK.

Sarcoma
|June 4, 2008
PubMed
Summary

Clear cell chondrosarcoma, a rare bone tumor, requires accurate initial diagnosis and treatment. Inadequate treatment of this chondrosarcoma variant increases recurrence and metastasis risks.

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Area of Science:

  • Orthopedic Oncology
  • Skeletal Radiology
  • Surgical Pathology

Background:

  • Clear cell chondrosarcoma is a rare chondroid tumor with a predilection for the epiphysis of long bones.
  • It represents a small percentage of all chondrosarcomas, making diagnosis and treatment challenging.
  • Misdiagnosis and suboptimal treatment can lead to significant morbidity.

Purpose of the Study:

  • To report on six cases of clear cell chondrosarcoma treated over 28 years.
  • To analyze the diagnostic and therapeutic outcomes in these patients.
  • To review the literature and emphasize the importance of appropriate initial management.

Main Methods:

  • Retrospective review of six clear cell chondrosarcoma cases.
  • Analysis of initial diagnoses, treatments, and outcomes.
  • Literature review on clear cell chondrosarcoma management.

Main Results:

  • Clear cell chondrosarcoma constituted 1.6% of all chondrosarcomas in the study period.
  • Half of the patients received an initial misdiagnosis.
  • Inadequate initial treatment was associated with high rates of local recurrence and metastasis.

Conclusions:

  • Accurate and timely diagnosis is crucial for clear cell chondrosarcoma.
  • Wide initial surgical excision is typically curative.
  • Inappropriate initial treatment significantly increases the risk of adverse outcomes, including recurrence and metastasis.