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Leiomyosarcoma of bone arising in association with a bone infarct

M Petra1, C L M H Gibbons, N A Athanasou

  • 1Department of Pathology Nuffield Department of Orthopaedic Surgery University of Oxford Nuffield Orthopaedic Centre Oxford OX3 7LD UK.

Sarcoma
|June 4, 2008
PubMed

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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...