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Elevated plasma total homocysteine in preeclampsia
Malihe Hasanzadeh1, Hossein Ayatollahi, Mahdi Farzadnia
1Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. HasanzademofradM@mums.ac.ir
Severe preeclampsia is linked to higher homocysteine levels. This study found elevated plasma homocysteine in women with severe preeclampsia compared to those with mild preeclampsia or normal pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Clinical Chemistry
Background:
- Preeclampsia is a serious pregnancy complication.
- Hyperhomocysteinemia, elevated homocysteine levels, is a potential risk factor.
Purpose of the Study:
- To investigate the association between hyperhomocysteinemia and preeclampsia.
- To compare plasma homocysteine levels in preeclamptic patients and healthy controls.
Main Methods:
- A case-control study involving 75 preeclamptic patients (37 mild, 38 severe) and 40 controls.
- Plasma total homocysteine levels were measured using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Mean plasma homocysteine levels were significantly higher in severe preeclampsia (13.8+/-7 mg/l) compared to mild preeclampsia (10.4+/-2.3 mg/l) and controls (8.8+/-2.8 mg/l).
- Groups were similar in age and body mass index.
Conclusions:
- Elevated plasma homocysteine levels are associated with severe preeclampsia.
- Hyperhomocysteinemia may play a role in the development of severe preeclampsia.
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