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Updated: Jul 4, 2026

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome

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Mayer-Rokitansky-Kuster-Hauser syndrome with hyperprolactinemia.

Dania H Al-Jaroudi¹, Ayda M Nasser

¹Department of Reproductive Medicine Unit, Minimally Invasive Gynecologic Surgery, Reproductive Medicine Unit, Women's Specialized Hospital, King Fahad Medical City, PO Box 59046, Riyadh 11525, Kingdom of Saudi Arabia. daljaroudi@kfmc.med.sa

Saudi Medical Journal

|June 4, 2008

Summary

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) with hyperprolactinemia is exceptionally rare. This case highlights a unique co-occurrence in an 18-year-old Saudi female with absent menses and Müllerian hypoplasia.

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Area of Science:

Reproductive Endocrinology
Gynecology
Medical Imaging

Background:

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a congenital disorder characterized by uterine and vaginal hypoplasia or aplasia.
Hyperprolactinemia is a condition of elevated prolactin levels, often associated with pituitary dysfunction.
The simultaneous occurrence of MRKH and hyperprolactinemia is exceedingly rare in medical literature.

Observation:

An 18-year-old Saudi female presented with primary amenorrhea.
Physical examination revealed normal secondary sexual characteristics but a rudimentary vagina (2 cm length).
Pelvic MRI confirmed Müllerian hypoplasia (Class I American Fertility Society), with a small uterus and cervix, and normal ovaries.

Findings:

Serum prolactin levels were significantly elevated at 1,517 mIU/L.
Cranial MRI ruled out a pituitary tumor or other structural abnormalities.
The patient was diagnosed with concomitant MRKH syndrome and hyperprolactinemia.

Implications:

This case underscores the importance of considering rare endocrine associations in patients with congenital anomalies.
Further research may elucidate potential shared etiologies or mechanisms between MRKH and hyperprolactinemia.
Management strategies may need to address both the reproductive tract anomaly and the hormonal imbalance.