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Updated: Jul 4, 2026

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
Published on: February 5, 2016
Colloidal metallic gold is not bio-inert
C L Brown1, M W Whitehouse, E R T Tiekink
1Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Science, Griffith University, Brisbane, Qld., 4111, Australia. c.l.brown@griffith.edu.au
Abstract:
Metallic gold (Au degrees ) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au degrees being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 10(3) times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.
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