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Immunogold Electron Microscopy

Immunogold Electron Microscopy

Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.

Microbial Leaching

Microbial Leaching

Microbial leaching, also known as bioleaching, is an environmentally favorable method for extracting metals from low-grade ores using specific microorganisms. This biotechnological approach is particularly valuable for mining operations targeting copper, gold, and uranium, where traditional extraction methods may be economically or environmentally impractical.Copper Leaching and Microbial CatalysisIn copper bioleaching, crushed ore is arranged into heaps and irrigated with a dilute sulfuric...

Colloidal precipitates

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

The Colloidal State

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

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Related Experiment Video

Updated: Jul 4, 2026

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

Published on: February 5, 2016

Colloidal metallic gold is not bio-inert.

C L Brown¹, M W Whitehouse, E R T Tiekink

¹Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Science, Griffith University, Brisbane, Qld., 4111, Australia. c.l.brown@griffith.edu.au

Inflammopharmacology

|June 4, 2008

Summary

Metallic gold nanoparticles, particularly Tyndall's purple, demonstrate potent anti-arthritic effects in rats. This colloidal metallic gold (CMG) shows significantly higher efficacy than traditional treatments, suggesting novel therapeutic potential.

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Last Updated: Jul 4, 2026

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

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Published on: February 5, 2016

Gold Nanostar Synthesis with a Silver Seed Mediated Growth Method

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Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

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Area of Science:

Biochemistry
Materials Science
Pharmacology

Background:

Monovalent gold (Au(I)) can biotransform into metallic gold (Au degrees), either through bioreduction or spontaneous dismutation.
Metallic gold nanoparticles (colloidal metallic gold, CMG) are being investigated for their biological properties.
Existing gold-based drugs like sodium aurothiomalate (Myocrysin) are used as disease-modifying antirheumatic drugs (DMARDs).

Purpose of the Study:

To review the preparation and biologically relevant properties of nano-particulate colloidal metallic gold (CMG).
To evaluate the anti-arthritic activity of a specific CMG preparation, Tyndall's purple.
To compare the efficacy and spectrum of action of CMG with a classic DMARD.

Main Methods:

Discussion of preparation methods for colloidal metallic gold (CMG).
Characterization of Tyndall's purple, a specific CMG preparation.
In vivo testing of anti-arthritic activity in rat models.
Comparative analysis against sodium aurothiomalate (Myocrysin).

Main Results:

Tyndall's purple, a characterized CMG preparation, exhibits potent anti-arthritic activity in rats.
The anti-arthritic efficacy of Tyndall's purple is approximately 1000 times greater than that of sodium aurothiomalate.
Tyndall's purple demonstrates a broader spectrum of action in rats compared to the classic DMARD.

Conclusions:

Colloidal metallic gold (CMG), particularly Tyndall's purple, shows significant promise as an anti-arthritic agent.
CMG offers superior potency and a wider range of therapeutic effects compared to established gold-based DMARDs.
Further research into CMG could lead to novel treatments for arthritis.