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Updated: Jul 4, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Silicosis mortality among young adults in the United States, 1968-2004
Jacek M Mazurek1, Michael D Attfield
1Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia WV26 505, USA. acq8@cdc.gov
Background:
To describe silicosis deaths in young (aged 15-44) adults in the U.S. during 1968-2004.
Methods:
We analyzed the National Center for Health Statistics multiple cause-of-death records.
Results:
Compared with silicosis decedents aged >or=45 years (n = 15,643), young decedents (n = 237) were more likely to have silicosis listed as the underlying cause of death (74.3% vs. 48.2%, P < 0.001), to be female (9.3% vs. 2.2%, P < 0.001) and black (37.1% vs. 11.7%, P < 0.001). Twenty-nine young silicosis decedents had industry and occupation information available. Occupations in construction and manufacturing industries were associated with significantly elevated proportionate mortality ratios for young silicosis deaths.
Conclusions:
Silicosis deaths occur among young adults. Because these deaths are likely to reflect more intense and recent exposures, the follow-back investigations into the work sites where these individuals were exposed to silica should be conducted.
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