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Quantification of Macronutrients Intake in a Thermogenetic Neuronal Screen using Drosophila Larvae
Published on: June 11, 2020
Transcriptional switches in the control of macronutrient metabolism
1School of Pharmacy and Life Sciences at The Robert Gordon University, Aberdeen, United Kingdom. alan.wise@rgu.ac.uk
Abstract:
This review shows how some transcription factors respond to alterations in macronutrients. Carbohydrates induce enzymes for their metabolism and fatty acid synthesis. Fatty acids reduce carbohydrate processing, induce enzymes for their metabolism, and increase both gluconeogenesis and storage of fat. Fat stores help control carbohydrate uptake by other cells. The following main transcription factors are discussed: carbohydrate response element-binding protein; sterol regulatory element-binding protein-1c, cyclic AMP response element-binding protein, peroxisome proliferator-activated receptor-alpha, and peroxisome proliferator-activated receptor-gamma.
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