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Related Experiment Video

Updated: Jul 4, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Can folate intake reduce arsenic toxicity?

Molly L Kile¹, Alayne G Ronnenberg

¹Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachsetts, USA.

Nutrition Reviews

|June 5, 2008

Summary

Folic acid supplementation improved arsenic metabolism in individuals with low folate levels. This suggests a potential link between folate intake and reduced arsenic toxicity risk.

Area of Science:

Environmental Health
Toxicology
Nutritional Science

Background:

Arsenic-contaminated groundwater poses a global health risk.
Inorganic arsenic is a carcinogen, with impaired metabolism increasing cancer risk.
Arsenic metabolism relies on a folate-dependent methylation process.

Purpose of the Study:

To investigate the impact of folic acid supplementation on arsenic metabolism.
To explore the relationship between folate status and arsenic toxicity susceptibility.

Main Methods:

A double-blind, placebo-controlled trial was conducted.
Participants with low plasma folate received folic acid supplementation for 12 weeks.
Urinary arsenic speciation and blood arsenic concentrations were measured.

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Main Results:

Folic acid supplementation increased the proportion of urinary arsenic excreted as dimethylarsinic acid (DMA).
Blood arsenic concentrations decreased following supplementation.
Individuals with specific folate metabolism gene polymorphisms excreted lower DMA proportions.

Conclusions:

Folic acid supplementation appears to enhance arsenic metabolism.
Findings support a significant interaction between folate and arsenic metabolism.
Further research is needed to confirm if high folate intake reduces arsenic toxicity risk.