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Hypertrophic cardiomyopathy with mild left ventricular remodeling: echocardiographic assessment using left

Kayo Hayato1, Makoto Okawa, Yoshihisa Matsumura

  • 1Department of Medicine and Geriatrics, Kochi Medical School, Oko-cho, Nankoku, Kochi 783-8505, Japan.

Journal of Cardiology
|June 5, 2008
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) with mild left ventricular (LV) remodeling shows reduced septal and apical wall motion. As dysfunction worsens, septal akinesis and thinning occur with LV enlargement.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart condition.
  • Left ventricular (LV) remodeling and systolic dysfunction are key features.
  • Understanding echocardiographic patterns is crucial for prognosis.

Purpose of the Study:

  • To investigate echocardiographic features of HCM with mild LV remodeling.
  • To correlate these features with wall motion abnormalities.
  • To identify predictors of disease progression.

Main Methods:

  • Retrospective analysis of 137 HCM patients.
  • Focus on 13 patients with mild LV systolic dysfunction (LVEF 35-50%).
  • Echocardiograms assessed using a 16-segment model for wall motion score index (WMSI).

Main Results:

  • HCM patients with mild LV dysfunction showed mild LV and left atrial dilatation.
  • Septal hypertrophy and impaired septal/apical wall motion were observed (septal WMSI 1.94).
  • Five patients progressed to LVEF < 35%, developing progressive LV enlargement, septal akinesis, and wall thinning.

Conclusions:

  • Reduced septal and apical wall motion characterize HCM with mild LV remodeling.
  • Progression of LV dysfunction involves septal akinesis, wall thinning, and LV cavity enlargement.
  • Posterolateral wall motion impairment remains relatively mild during progression.
Abstract

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