Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell shape: taking the heat.

Patricia Kunda1, Jennifer L Rohn, Buzz Baum

  • 1MRC Laboratory for Molecular Cell Biology, and the Department of Cell and Developmental Biology, UCL, Gower Street, London, UK. pkunda@ucl.ac.uk

Current Biology : CB
|June 5, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing.

British journal of cancer·2026
Same author

3D epithelial cell topology tunes signaling range to promote precise patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Rethinking urinary tract infections in women with abdominal pain in pregnancy: a prospective case-control study.

BMC pregnancy and childbirth·2026
Same author

The physical properties of ascitic fluid enhance metastatic potential by inducing mitotic abnormalities and multinucleation in ovarian cancer.

BMC cancer·2026
Same author

Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The mechanism of cell-cycle-dependent proteasomal degradation of archaeal ESCRT-III homolog CdvB in Sulfolobus.

The EMBO journal·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
Same journal

Tracking Satb2-positive retinal ganglion cells in zebrafish unveils developmental functional reorganization.

Current biology : CB·2026
Same journal

RhoGAP54D promotes cell size asymmetry and inhibits pulsatile myosin activity in Drosophila neural stem cells.

Current biology : CB·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
See all related articles

An extracellular protein called Spam helps fruit fly mechanosensory organs maintain cell structure during heat shock. This protein prevents cell damage caused by water loss, crucial for sensory function.

Area of Science:

  • Cell biology
  • Biophysics
  • Developmental biology

Background:

  • Cell architecture preservation is vital for biological processes.
  • Mechanosensory systems translate cellular shape changes into organism behavior.
  • Heat shock can cause cellular damage through water loss.

Purpose of the Study:

  • To investigate the role of extracellular proteins in cellular stress response.
  • To understand how mechanosensory organs maintain integrity under heat shock.
  • To identify mechanisms protecting cells from dehydration during thermal stress.

Main Methods:

  • Utilized fruit fly (Drosophila melanogaster) models.
  • Investigated the function of the extracellular protein Spam.
  • Assessed cellular architecture and mechanosensory organ function under heat shock conditions.

Related Experiment Videos

Main Results:

  • The extracellular protein Spam was identified as crucial for cell preservation.
  • Spam protects mechanosensory organs from damage caused by heat shock-induced water loss.
  • Fruit flies lacking Spam exhibit compromised mechanosensory function after heat exposure.

Conclusions:

  • Spam plays a critical role in protecting cellular structure and function in fruit fly mechanosensory organs.
  • Understanding Spam's mechanism offers insights into cellular resilience against environmental stressors.
  • This finding has implications for studying mechanosensation and stress adaptation in biological systems.