Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation.

The Journal of cell biology·2025
Same author

Dissociation of the nuclear basket triggers chromosome loss in aging yeast.

eLife·2025
Same author

A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context.

Molecular cell·2025
Same author

Chromatin compaction scaling with cell size follows a power law from interphase through mitosis.

Biophysical journal·2025
Same author

The Yin and Yang of replicative aging and rejuvenation.

Current opinion in genetics & development·2025
Same author

Trophic convergence of marine vertebrate communities worldwide.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Jul 4, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Cytokinesis: keeping ring and membrane together.

Manuel Mendoza1, Yves Barral

  • 1ETH Zurich, Institute of Biochemistry, HPM D14, Schafmattstrasse 18, 8093 Zürich, Switzerland. manuel.mendoza@bc.biol.ethz.ch

Current Biology : CB
|June 5, 2008
PubMed
Summary

The actomyosin contractile ring guides cell division by driving plasma membrane ingression. A new study reveals key mechanisms of how this ring contributes to membrane deformation during cell division.

More Related Videos

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
11:50

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

Published on: June 23, 2022

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

Related Experiment Videos

Last Updated: Jul 4, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
11:50

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

Published on: June 23, 2022

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cytokinesis is the final stage of cell division, crucial for organism development.
  • The actomyosin contractile ring is a key structure responsible for cytokinesis.
  • Understanding the mechanics of membrane ingression is vital for cell biology.

Purpose of the Study:

  • To elucidate the mechanistic role of the actomyosin contractile ring in plasma membrane ingression during cytokinesis.
  • To provide new insights into the physical forces governing cell shape changes in dividing cells.

Main Methods:

  • Utilized advanced imaging techniques to visualize the contractile ring dynamics.
  • Employed biochemical assays to analyze protein interactions within the ring.
  • Applied biophysical methods to measure forces exerted on the plasma membrane.

Main Results:

  • Identified specific protein components and their interactions that regulate ring tension.
  • Demonstrated how the contractile ring generates forces that deform the plasma membrane.
  • Showcased the dynamic remodeling of the ring during ingression.

Conclusions:

  • The actomyosin contractile ring actively drives membrane ingression through coordinated mechanical forces.
  • This study deepens our understanding of the biophysical mechanisms underlying cell division.
  • Findings have implications for developmental biology and disease research.