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Updated: Jul 4, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Progression from macular retinoschisis to retinal detachment in highly myopic eyes is associated with outer lamellar
N Shimada1, K Ohno-Matsui, T Yoshida
1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Aims:
To investigate the morphological changes that occur during the development of an early retinal detachment (RD) from a myopic macular retinoschisis (MRS) by optical coherence tomography (OCT).
Methods:
The OCT images of five eyes of five consecutive patients with myopic MRS who developed an RD during the follow-up period were studied.
Results:
The progression from MRS to early RDs went through four stages. In stage 1, OCT images appeared to show a focal irregularity of the thickness of external retina. In stage 2, an outer lamellar hole developed within the thickened area and a small RD developed. In stage 3, the column-like structures overlying the hole seemed to be separated horizontally, and the outer lamellar hole appeared to be larger vertically. In stage 4, the upper edge of the external retina was further elevated and attached to the upper part of the retinoschisis layer accompanied by further enlargement of the RD.
Conclusions:
This longitudinal study showed that the progression from myopic MRS to RD passes through four stages, and the formation of an outer lamellar hole predisposes the retina to a RD. These OCT findings might be useful for considering the surgical indication for eyes with a myopic MRS.
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