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IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways

Yang Hu1, Xiaoyu Hu, Laurence Boumsell

  • 1Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|June 5, 2008
PubMed
Summary

Interferon-gamma (IFN-gamma) halts monocyte migration by disrupting actin cytoskeleton remodeling and cell polarization. This discovery reveals a novel mechanism for controlling cell movement during inflammation and immune responses.

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