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Updated: May 10, 2026

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
Published on: December 10, 2012
Extra-chromosomal elements and the evolution of cellular DNA replication machineries
Adam T McGeoch1, Stephen D Bell
1Adam T. McGeoch is at the MRC Cancer Cell Unit, Hutchison MRC Centre, Hills Road, Cambridge, CB2 0XZ, UK.
Abstract:
DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the role that lateral gene transfer by extra-chromosomal elements might have had in shaping the replication machinery and even modulating the manner in which host cellular genomes are replicated.
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