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Related Concept Videos

Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
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The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
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Ole Isacson: Development of New Therapies for Parkinson's Disease
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Published on: April 29, 2007

Challenges for translational psychopharmacology research--some basic principles.

Klaus A Miczek1, Harriet de Wit

  • 1Tufts University, 530 Boston Avenue (Bacon Hall), Medford, MA 02155, USA. klaus.miczek@tufts.edu

Psychopharmacology
|June 5, 2008
PubMed
Summary

Translating preclinical findings to clinical applications requires focused animal models targeting core psychiatric symptoms. Converging evidence and validated models enhance clinical relevance and treatment discovery.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Translational Research

Background:

  • Translating preclinical findings to clinical applications is a significant challenge in psychiatric research.
  • Developing relevant animal models of human disorders requires careful consideration of numerous factors.

Purpose of the Study:

  • To outline key principles for successful translation of preclinical data to clinical applications.
  • To guide the development of more clinically relevant animal models of human psychiatric disorders.

Main Methods:

  • Review and synthesis of recurring principles in translational research.
  • Analysis of criteria for evaluating the validity and utility of preclinical models.

Main Results:

  • Translation is improved by focusing models on core symptoms and incorporating species-normative adaptations.
  • Converging evidence from multiple procedures and high construct validity enhance clinical relevance.
  • Model choice reflects theoretical approach; validation predicts treatment success for similar mechanisms.

Conclusions:

  • Preclinical models must be carefully constructed and validated to yield clinical benefits.
  • Defining psychological processes in behavioral and neural terms is crucial for studying affect and cognition in models.