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Updated: Jul 4, 2026

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
Published on: January 12, 2020
[Classification of systemic vasculitides]
Loïc Guillevin1, Christian Pagnoux
1Service de médecine interne, Centre de référence maladies rares Vascularites et Sclérodermies systémiques, hôpital Cochin, Université Paris-V-René-Descartes, Paris. loic.guillevin@cch.aphp.fr
Abstract:
Systemic vasculitides are characterized by different histological aspects: fibrinoid necrosis of the arterial wall, giant cell arteritis, non-necrotizing arteritides without granuloma or giant cell infiltration. Each histological form is associated with a spectrum of diseases with variable clinical expression: giant cell angeitides, such as Takayasu's arteritis and giant cell arteritis, necrotizing angeitides, such as polyarteritis nodosa, Kawasaki disease, Wegener's granulomatosis, Henoch-Schönlein purpura or Churg-Strauss syndrome. The detection of anti-neutrophilic cytoplasmic antibodies (ANCA) also makes it possible to classify necrotizing vasculitides by isolating a group of diseases different from necrotizing vasculitidies without ANCA (Wegener's granulomatosis, microscopic polyangitis, allergic granulomatous angiitis).
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