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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Related Experiment Video

Updated: Jul 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Behçet's disease].

Achille Aouba1

  • 1Université de Paris5 René-Descartes. achille.aouba@nck.aphp.fr

La Revue Du Praticien
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Behçet

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Last Updated: Jul 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Rheumatology and Immunology
  • Ophthalmology
  • Vascular Medicine

Background:

  • Behçet's disease is a systemic vasculitis characterized by oral/genital aphthosis and uveitis.
  • Clinical manifestations are diverse, including cutaneous signs and organ involvement (entero-, angio-, neuro-Behçet).
  • Diagnosis can be challenging due to the absence of specific clinical or biological markers, especially with incomplete diagnostic criteria.

Purpose of the Study:

  • To review the protean clinical manifestations of Behçet's disease.
  • To highlight diagnostic challenges in incomplete or atypical presentations.
  • To discuss the current understanding of prognosis and emerging therapeutic strategies.

Main Methods:

  • Review of clinical presentations and diagnostic criteria for Behçet's disease.
  • Analysis of prognostic factors, particularly ocular involvement.
  • Evaluation of current and novel therapeutic approaches, including anti-TNFalpha agents.

Main Results:

  • Behçet's disease presents with a wide spectrum of symptoms beyond the classic triad.
  • Diagnostic difficulties persist, impacting timely intervention.
  • Prognosis remains guarded, especially for ocular complications, due to lack of curative treatments.
  • Anti-TNFalpha therapies show promise for severe, refractory cases, but their long-term efficacy and role require further definition.

Conclusions:

  • Behçet's disease requires a high index of suspicion due to its varied presentation.
  • Improved diagnostic strategies and further research into etiology are needed.
  • Anti-TNFalpha agents represent a significant advancement, necessitating further studies to establish optimal use and long-term outcomes.