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Related Experiment Video

Updated: Jul 4, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Visfatin expression is elevated in normal human pregnancy.

S A Morgan1, Jonathon B Bringolf, E R Seidel

  • 1Department of Physiology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.

Peptides
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Pregnancy significantly increases visfatin gene expression in omental fat, potentially regulating maternal and fetal glucose metabolism. This adipokine mimics insulin

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Area of Science:

  • Endocrinology and Metabolism
  • Reproductive Biology

Background:

  • Visfatin is a novel adipokine with insulin-mimetic properties, influencing glucose transport.
  • Its role during pregnancy, a state of altered glucose metabolism, remains largely unexplored.

Purpose of the Study:

  • To investigate the impact of pregnancy on visfatin gene expression, circulating levels, and local concentrations in omental fat and placenta.
  • To compare visfatin levels in pregnant women with lean, obese, and obese diabetic women.

Main Methods:

  • Measurement of visfatin expression and concentration in omental fat, blood, and placenta from four cohorts: lean controls, pregnant women, obese women, and obese diabetic women.
  • Techniques included quantitative real-time PCR, immunohistochemistry (IHC), and immunoblotting.
  • In vitro studies assessed visfatin's effect on glucose transport in 3T3-L1 preadipocytes.

Main Results:

  • Omental fat visfatin expression was seven times higher in pregnant women compared to lean controls.
  • Placenta demonstrated substantial visfatin mRNA expression, translated into protein.
  • Serum visfatin levels were higher in pregnant women, but did not fully reflect the increase in omental fat mRNA.

Conclusions:

  • Pregnancy is associated with a selective increase in visfatin gene expression in omental fat and significant expression in the placenta.
  • Visfatin potently induces glucose transport, suggesting a potential role in regulating maternal/fetal glucose metabolism and distribution during pregnancy.