Cerebral meningioangiomatosis in a CD-1 mouse: a case report and comparison with humans and dogs
Related Experiment Video
Updated: Jul 4, 2026
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
Published on: September 4, 2017
Emmanuelle Balme1, Daniel Robert Roth, Elias Perentes
1Department of pathology, Veterinary school of Alfort, 94704 Maisons-Alfort, France.
Abstract:
Meningioangiomatosis is a rare proliferative disorder of the central nervous system. Several cases have been described in humans, a few in dogs, one case in a cow and one in a horse; meningioangiomatosis has never been recorded in rodents. The pathogenesis of this condition remains obscure and it is uncertain whether it represents a neoplastic or malformative process. Meningioangiomatosis is usually characterized by a plaque-like leptomeningeal proliferation of mainly spindle-shaped cells and small blood vessels, extending along the Virchow-Robin spaces into the adjacent neural parenchyma. In this report, we presented a brain lesion displaying the histopathological key features of the meningioangiomatosis and involving the base of the cerebrum (fronto-basal area) and the brainstem, found in a male CD-1 mouse. The histopathological and immunohistochemical results are discussed, and compared with those previously reported in other cases of meningioangiomatosis.
Insights
Meningioangiomatosis, a rare central nervous system disorder, was identified in a CD-1 mouse, marking the first recorded instance in rodents. This finding expands our understanding of the condition
Area of Science:
- Neuropathology
- Comparative Pathology
Background:
- Meningioangiomatosis is a rare central nervous system (CNS) proliferative disorder.
- Its pathogenesis is unclear, with debate on whether it is neoplastic or malformative.
- Previously documented in humans, dogs, cows, and horses, but not rodents.
Observation:
- A brain lesion exhibiting key histopathological features of meningioangiomatosis was identified.
- The lesion involved the fronto-basal cerebrum and brainstem of a male CD-1 mouse.
- This represents the first documented case of meningioangiomatosis in a rodent.
Findings:
- Histopathological and immunohistochemical analyses confirmed the lesion's features consistent with meningioangiomatosis.
- The findings were compared with previously reported cases in other species.
- The study details the specific presentation in a rodent model.
Implications:
- This case expands the known host range for meningioangiomatosis to include rodents.
- It provides a new model for studying the pathogenesis and biology of this rare CNS disorder.
- Further research in rodent models may elucidate the neoplastic versus malformative nature of meningioangiomatosis.
