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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Hedgehog signalling in endocrine development and disease.

Peter J King1, Leonardo Guasti, Ed Laufer

  • 1Barts and the London School of Medicine, Centre for Endocrinology, London EC1M 6BQ, UK. p.j.king@qmul.ac.uk

The Journal of Endocrinology
|June 6, 2008
PubMed
Summary

The hedgehog (Hh) signaling pathway regulates cell development and tissue patterning. This review updates recent findings on Hh signaling in vertebrate development, maintenance, and diseases of endocrine tissues.

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Endocrinology

Background:

  • The hedgehog (Hh) pathway is crucial for conserved cellular processes.
  • Hh signaling regulates cell differentiation, proliferation, and tissue patterning.
  • Disruptions in Hh signaling lead to significant pathologies.

Purpose of the Study:

  • To provide an updated review of recent findings in vertebrate Hh signaling.
  • To elucidate the role of Hh signaling in endocrine tissue development.
  • To describe Hh signaling's contribution to endocrine tissue maintenance and pathology.

Main Methods:

  • Literature review of recent advancements in Hh signaling research.
  • Analysis of studies focusing on vertebrate models.
  • Synthesis of data on Hh pathway involvement in endocrine systems.

Main Results:

  • Recent studies highlight novel roles of Hh signaling in tissue development.
  • Hh pathway activity is essential for normal endocrine gland function.
  • Aberrant Hh signaling is implicated in various endocrine pathologies.

Conclusions:

  • Vertebrate Hh signaling is vital for endocrine tissue homeostasis.
  • Further research into Hh pathway modulation may offer therapeutic strategies for endocrine diseases.