Related Experiment Video
Updated: Jul 4, 2026
12:18
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Invasive infections with community-associated methicillin-resistant Staphylococcus aureus after kidney
Oluwadamilola A Adeyemi1, Chao Qi, Teresa R Zembower
1Divisions of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Journal of Clinical Microbiology
|June 6, 2008
Summary
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause invasive infections in kidney transplant recipients. Clinicians should consider CA-MRSA in transplant patients with skin and soft tissue infections.
Area of Science:
- Infectious Diseases
- Nephrology
- Transplantation Immunology
Background:
- Organ transplant recipients are immunocompromised and susceptible to various infections.
- Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing prevalence.
Observation:
- Two kidney transplant recipients developed invasive infections.
- These infections were caused by Panton-Valentine leukocidin-positive CA-MRSA.
Findings:
- Panton-Valentine leukocidin-positive CA-MRSA strains can cause severe invasive infections post-kidney transplantation.
- The clinical presentation involved skin and soft tissue infections.
Implications:
- CA-MRSA should be included in the differential diagnosis for infections in organ transplant recipients.
- Early recognition and appropriate management of CA-MRSA infections are crucial for patient outcomes in transplantation.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...