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Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats.

Dianne P Figlewicz1, Jennifer L Bennett, Sepideh Aliakbari

  • 1Metabolism/Endocrinology, 151 VA Puget Sound Health Care System, 1660 So. Columbian Way, Seattle WA 98108, USA. latte@u.washington.edu

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|June 6, 2008
PubMed
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Insulin acutely reduces sucrose intake and motivated feeding behaviors. Specific brain regions, like the arcuate nucleus and ventral tegmental area, are key sites for insulin

Area of Science:

  • Neuroscience
  • Endocrinology
  • Behavioral Science

Background:

  • Insulin plays a chronic role in the central nervous system (CNS) regulating energy balance and reducing brain reward function.
  • Acute insulin actions on CNS reward pathways and feeding behavior are less understood.

Purpose of the Study:

  • To compare the acute effects of insulin on palatable food intake in distinct behavioral tasks.
  • To identify specific CNS sites where insulin modulates reward-driven feeding.

Main Methods:

  • Administered insulin (5 mU) into specific CNS sites: arcuate nucleus (ARC), paraventricular nucleus (PVN), nucleus accumbens, and ventral tegmental area (VTA).
  • Assessed effects on progressive ratios sucrose self-administration.
  • Evaluated insulin's antagonism of micro opioid (DAMGO)-stimulated sucrose feeding.

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Main Results:

  • Insulin in the ARC significantly suppressed sucrose self-administration (75% of control).
  • Insulin antagonized DAMGO-induced sucrose feeding specifically in the VTA (53% of DAMGO-induced intake).
  • Sucrose intake modulation by insulin occurred in an anatomically specific manner within CNS reward circuitry.

Conclusions:

  • Acute insulin administration can decrease motivated sucrose intake and feeding behaviors.
  • Specific CNS sites, including the ARC and VTA, are critical for insulin's acute effects on reward and feeding.
  • Adiposity signals like insulin influence palatable food ingestion through anatomically defined pathways.