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Updated: Jul 4, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
HIV Gag-specific immune responses predict the rate of CD4 decline
Yoav Peretz1, Christos M Tsoukas, Nicole F Bernard
1Research Institute of McGill University Health Center, Montreal, Quebec, Canada.
Abstract:
In the present study, we assessed whether Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline. Although neither the breadth nor the magnitude of the proteome-wide HIV-specific IFN-gamma response correlated with viral load or rate of CD4 decline, the preferential targeting of Gag is associated with slower annual CD4 T cell decline.
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