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Updated: Jul 4, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
New targets for therapy of sarcoma
John M Magenau1, Scott M Schuetze
1Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Current Opinion in Oncology
|June 6, 2008
Summary
Targeted therapies show promise for advanced sarcoma when standard treatments fail. Research focuses on molecular changes and specific pathways for future combination treatments.
Area of Science:
- Oncology
- Translational Research
- Molecular Biology
Background:
- Advanced sarcoma treatment options are limited.
- Sarcomas are a heterogeneous group of cancers.
- Standard first-line regimens include doxorubicin, ifosfamide, and gemcitabine with docetaxel.
Purpose of the Study:
- To review emerging trends in targeted therapy for sarcoma.
- To explore molecular changes amenable to targeted treatment.
- To discuss the role of biologic inhibitors in sarcoma management.
Main Methods:
- Review of translational research in sarcoma.
- Analysis of early clinical trials for targeted agents.
- Focus on aberrant signaling pathways like mTOR and tyrosine kinase.
Main Results:
- Targeted therapies offer potential for advanced sarcoma.
- Agents targeting C-KIT, PDGF-R, mTOR, VEGF-R show some efficacy.
- Insulin-like growth factor-1 receptor is a promising target.
Conclusions:
- Targeted agents are likely to play a long-term role in sarcoma treatment.
- Identifying critical pathways and susceptible subtypes is key.
- Future research will focus on novel combinations of targeted therapies.
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